Reduction of laser energy might prevent this potential complication. Comparison of transmyocardial revascularization with medical therapy in patients with refractory angina. Therefore, we should clearly identify the ischemic area for laser therapy. Transmyocardial revascularization with a carbon dioxide laser in patients with end-stage coronary artery disease. TMLR might chronically impair the myocardium function by enhancing regional scar formation. More fibrosis and less vasculature were demonstrated 12 weeks after laser therapy in group I.Īngiogenic response to the Holmium:YAG laser in the nonischemic myocardium is nonspecific and unsustainable. Gradual decline of vascular density occurred during a later follow-up. The initial increase in vascular density within the laser channel remnants and the surrounding areas was more marked in group I than in group II. Changes in vascular density demonstrated a similar pattern in both groups over time. All laser channel remnants were composed of granulation tissue, fibrosis, and various amounts of vascular structures. No patent laser channels were identified.
#High energy small eximo laser revascularization series#
Then the animals were sacrificed (one every 2 or 3 days up to 6 weeks, then one every week) to give a series of hearts from 1 week to 12 weeks following TMLR. TMLR was applied to the anterolateral wall of the left ventricle. The animals were randomized to two groups (high-energy (1.4 J/pulse) TMLR group and low-energy (0.6 J/ pulse) TMLR group).
We study the time course of histological appearance following high- and low-energy TMLR in a rodent model of normal myocardium. However, the biological response to laser of different energy doses in nonischemic myocardium has not been well studied. Transmyocardial laser revascularization (TMLR) has been shown to induce angiogenesis and improve regional myocardial blood flow.
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